Ekiwuka ekiyitibwa Astragalus membranaceus, omuddo oguwangaala mu kika kya Leguminosae, gukozesa ekikolo kyagwo ekikalu ng’eddagala. Mu ddagala ly'ekinnansi ery'Abachina (TCM), omulimu gwayo omukulu gwe "tonifying Qi and consolidating the exterior," era gutera okukozesebwa ku bubonero ng'obutaba na Qi, obukoowu, okutuuyana okwetongodde, okutuuyana ekiro, n'okukwatibwa obuwuka obw'ebweru. Endowooza ya..."Qi".mu TCM ndowooza ya nkola etaliimu, ekitundu ku makulu gaayo kikwatagana nnyo n’ekyo eddagala ery’omulembe lye lyeyogerako"obusimu obuziyiza endwadde." Ebirungo ebiyitibwa Astragalus polysaccharides-ebirungo ebikulu ebikola obulamu ebya Astragalus-biwa omusingi gwa ssaayansi ogw'okuvvuunula endowooza ya TCM eya "Qi tonification" mu ndowooza ez'omulembe nga obuyambi bw'abaserikale b'omubiri, olw'emirimu gyabyo egy'amaanyi egy'okukyusa obusimu obuziyiza endwadde, okuziyiza obuwuka obuleeta obulwadde, n'okuziyiza-obukoowu[1].
Mu mwaka gwa 2023, akakiiko k’ebyobulamu mu ggwanga lya China kaafulumya Ekirangiriro No. 9, nga kakkiriza Astragalus, Codonopsis, n’ebintu ebirala musanvu okuyingizibwa ebipya ku lukalala lw’ebintu ebikozesebwa mu buwangwa ng’emmere n’eddagala, bwe kityo ne kigaziya ku ngeri gye biyinza okukozesebwamu.
(Ensibuko y’ebifaananyi: Akakiiko k’ebyobulamu mu ggwanga aka People’s Republic of China)
Newankubadde nga Astragalus polysaccharides (APS) bye bitundu ebikulu ebikola mu Astragalus, ekyenda ky’omuntu tekirina enzymes ezigaaya emmere ezeetaagisa okusaanuusa butereevu polysaccharides ezo enzibu. APS za macromolecular ezifunibwa okuyita mu nkola eza bulijjo ez’okuggyamu tezisobola kusala mangu epithelium y’ekyenda, ekivaamu obulungi bw’okunyiga obutono ennyo. Ekitundu ekitono kyokka kye kiyingira mu ntambula y’ensengekera (systemic circulation), nga eno y’ensonga enkulu eviirako obutabeera na bulamu bwazo obutono.
Okumenyawo - Okuzimbulukusa eddagala ly'ekinnansi ery'Abachina
Olw’okunyiga kwazo obutereevu okutono, Astragalus polysaccharides okusinga zisigala munda mu nkola y’ekyenda. Endowooza enkulu eziriwo kati ziraga nti APS yeeyisa nnyo ng’ekika eky’enjawulo ekyaeddagala eriyitibwa prebiotic. Ebikosa byabwe tebyesigamye kuokubeera nga banywezeddwa, naye okusinga kuokubeera nga kizimbulukuse. Nga bakola nga substrates for gut commensal microbes, APS zikyusibwakyusibwa ebika bya bakitiriya eby’omugaso, bwe kityo ne byongera ku bioavailability yaabwe[2].
Microbial fermentation of Chinese medicinal materials represents a "crystallization of traditional wisdom." Historical processing methods leveraged natural microorganisms interacting with herbs to achieve the purposes of "reducing toxicity, enhancing efficacy, and transforming medicinal properties." At its core, this process reflects the enkolagana ey’okukwatagana wakati w’enkyukakyuka y’obuwuka obutonotono n’ebirungo ebikola ebimera. Okwawukanako n’okulongoosa mu ngeri ey’ekinnansi (okugeza, okwokya, okusiika) oba okulongoosa mu ddagala (okugeza, okusiika vinegar-okusiika, wayini-okusiika), okuzimbulukusa obuwuka obutonotono kuwa ebirungi bisatu ebikulu:embeera z’ensengekera ennyangu, obulagirizi obw’amaanyi, n’enjawulo y’ebintu ebingi.
Okuzimbulukusa kw’obuwuka obutonotono kulongoosa nnyo okusinga okunyiga
Enkola y’okuzimbulukusa ekola ng’engeri ey’omulembe eyanga tekunna-okugaaya emmere. Ebika bya probiotic ebitongole bifulumya enzymes "ezikutula" ddala APS ey'obuzito bwa molekyu- obunene mu lunyiriri lw'obutundutundu bwa polysaccharide obw'obuzito obutono-molekyulu-. Omugaso ogusinga okuba ogw’amangu ogw’enkyukakyuka eno gwe aokweyongera okw’amaanyi mu kunyiga, okusobozesa ebitundu ebikola okuyingira mu ntambula y’ensengekera mu ngeri ennungi.
Kyokka, emigaso gy’okuzimbulukusa gisukka nnyo ku kulongoosa mu kugiyingiza. Okunoonyereza kulaga nti ebitundu bino eby’obuzito obutono-molekyu-ebikolebwa okuyita mu kuzimbulukusa obuwuka obutonotono mu butuufu bye...obubonero obukulu obusitula obusimu obuziyiza endwadde. Bw’ogeraageranya ne native macromolecular APS, obutundutundu obutono bulina ebifo eby’okutegeera abaserikale- eby’oku ntikko n’okukola kw’ebiramu okunywezeddwa. Zikyusa bulungi emirimu gya macrophages, T lymphocytes, n’obutoffaali obulala obukulu obw’abaserikale b’omubiri, bwe batyo ne balaga ebikolwa eby’enjawulo mu kulungamya homeostasis y’abaserikale b’omubiri n’okutumbula obusobozi bw’okuziyiza omugenyi[3].
Okunoonyereza okungi kulaga buli kiseera ekyopolysaccharides ezirina obuzito obutono-molecular-okutwalira awamu ziraga emirimu egy’amaanyi egy’obusimu obuziyiza endwadde. Okugeza nga:
Ginseng polysaccharides ezirina obuzito obutono-molecular-(10.2 kDa) ziraga okukola kwa macrophage okusingako bw’ogeraageranya ne bannaabwe abazitowa ennyo-molecular-(21.3 kDa)[4];
Low-molecular-weight glycyrrhiza polysaccharides (GP) zikwata bulungi ku kulungamya abaserikale b’omubiri mu byenda[5];
Ebirungo ebirala ebikola ku busimu obuziyiza endwadde okuva mu ffene, .Ensigo eziyitibwa Pueraria lobata, n’ensonda ezifaanagana nazo ziraga emirimu egisinga obulungi mu buzito bwa molekyu- obw’enjawulo[6].
Okutwalira awamu, bino ebizuuliddwa biggumiza...omulimu ogw’omu makkati ogw’okukendeeza ku buzito bwa molekyu-mu kwongera ku bulung’amu bw’obusimu obuziyiza endwadde (immunomodulatory efficacy) obwa polysaccharides.
