Licorice Extract: Okusumulula Okumenya kwa Sayansi Ku "Super-Photon" Licochalcone A ey'omu kamwa Okwerusa

"Olususu olutangaavu lukweka obusobozi kikumi; olususu oluddugavu lwonoona buli kimu."

Ng’ekimu ku butale obukulu mu nsi yonna obw’ebintu ebikola ku by’okwewunda mu kamwa, obunene bw’akatale ka China busuubirwa okutuuka25.57 obuwumbi bwa RMB mu 2025, okugenda mu maaso okutuuka ku kufuuka akatale akasinga obunene mu nsi yonna nga a3.8% compound omuwendo gw’okukula kw’omwaka.
Mu kitundu kya China ekikola ku by’okwewunda mu kamwa,...ekika ky’okwerusa kifuna okukula okw’amaanyi. Okugeza ku JD.com mu...kwata y’omwaka ogusooka ogwa 2025(Ekifaananyi 1), .SKU empya ezisoba mu 3,500zatongozebwa mu kitundu ky'okwerusa-nga zikola ebitundu nga 90% ku bintu byonna ebipya eby’okwewunda mu kamwamu kiseera kye kimu, okusukka wala ebika ebirala ebitonotono nga anti-okukaddiwa, amazzi, n'okuziyiza enviiri-okufiirwa [1].

Severe Homogenization of Whitening Ebirungo-Ebikolwa Ebipya Byetaagibwa Mu Mangu

Ebirungo ebikulu eby’okwerusa mu kamwa mu kiseera kino ku katale mulimu...glutathione (ekirungo kya glutathione)., eddagala eriyitibwa ergothioneine, neekirungo ky’ennyaanya enjeru. Ebibiri ebisooka okusinga essira balitadde ku...antioxidation ne free-okusaanyawo ebiwuka ebiyitibwa radical, ate ng’ekyo eky’oluvannyuma kiraga ntiokukuuma ebifaananyiemigaso (Table 1).

Wabula ebika bya sayizi zonna byolekedde okukoowa (concept fatigue). Ebintu ebyerusa byeyongera okufaanagana mu kulonda ebirungo, ekiviirako abaguzi okubulwa obwagazi eri ensonga zino ez’omuwendo eziddiŋŋana. Akatale kali mu bwetaavu obw’amangu...ebipya ebikola ebyerusa mu kamwaokufuyira amaanyi amapya mu kiti ky’obulungi bw’omu kamwa obuyimiridde.

Eky’okuddamu mu kusaba kuno kiyinza okuba nga kiri mu...ekitongole ky’ebizigo.

Olw'okulinnya kw'omulembe gwa "cosmetics–food homology", ekitongole ky'okulabirira olususu kivuddemu endowooza nnyingi ez'ebirungo ezimanyiddwa ennyo ez'omutendera gw'okwewunda kw'omu kamwa.Ekirungo kya Ergothioneineyasibuka mu kifaananyi kya Helena RubinsteinBandage Omuddugavuebizigo (Ekifaananyi 2), Later Lift kye yakyusa n'efuuka ekintu kyayo eky'omu kamwa ekya "Ice Crystal Skin" (Ekifaananyi 3). Endowooza ya...ekirungo kya astaxanthinyava mu PROYA'sDouble Antilayini (Ekifaananyi 4), n’eddirirwa eya Me TodayGlow Essasi ly'essasi(Ekifaananyi 5).

Ekirungo ekiddako ekiyinza okuba eky’emmunyeenye, .eddagala eriyitibwa glabridin, kisibuka mu bya GuyuAurora Licorice ow’ekika kya Licoriceseries (Ekifaananyi 6). Layini eno ey’okwerusa, nga yeesigamiziddwa ku glabridin, yayamba Guyu okutuuka ku ekyoObuwumbi bwa RMB 5 mu GMV. Nga China esinga okukola skincare brand ezimbiddwa okwetoloola glabridin, Guyu eraze okukula okubwatuka okusinga wala brands z’awaka nga PROYA ne Kans.

Kyokka mu by’awakaobulungi bw’omu kamwasector, glabridin esigala nga okusinga tekozesebwa-okutondawo omukisa omupya ogw’amaanyi eri ebika by’okwewunda mu kamwa.

Ebifaananyi 2 & 3: Helena Rubinstein Black Bandage n’oluvannyuma Lift Ice Crystal Skin (erimu ergothioneine)

Ebifaananyi 4 & 5: PROYA Double Anti ne Me Today Glow Shot (erimu astaxanthin)

Ekifaananyi 6: Guyu Aurora Licorice Series (ekoleddwa ne glabridin) .

Enkola za Licorice mu kwerusa olususu

Licorice alina ebyafaayo bingi eby’okukozesebwa mu kufumba n’eddagala mu China era nga ali mu kibinja kya adual-kozesa emmere–eddagalaekirungo. Mu nkola ya classic ey’ekinnansi ey’Abachina ey’okwewunda"San Bai Gan Cao Tang" - Omuntu w'abantu., licorice egattibwa ne Atractylodes, White Peony, ne Poria okutunuulira ebiruma olususu nga hyperpigmentation, melasma, roughness, n’okukala. Licorice era ali mu ndagiriro z’ekinnansi ezimanyiddwa ennyo ez’okwerusa nga"Yu Rong San".ne"Yu Nü Tao Hua Fen."

Okunoonyereza okw’omulembe kulaga nti licorice alimu ebirungo ebikola obulamu ngaekirungo kya glycyrrhizin, asidi wa glycyrrhetinic, needdagala eriyitibwa glabridin, ezikwata obulungi ku melanocytes ezikwatibwako okwonooneka kw’ekitangaala, situleesi y’okwokya, n’ebizimba-ekikendeeza ku mikisa gy’okukola melanin esukkiridde. Okugatta ku ekyo, licorice esobola okukendeeza ku muwendo gwa melanin nga...okuziyiza ekirungo kya tyrosinase, enziyiza enkulu eyenyigira mu kukola melanogenesis.

"Obulwadde bwa Super Photonic obw'omu kamwa" - Glabridin

Ebika bya licorice ebiwerako biriwo, era bisatu bikkirizibwa okukozesebwa mu China:Obulwadde bwa Glycyrrhiza uralensis, Ensigo eziyitibwa Glycyrrhiza inflata, neGlycyrrhiza enviiri eziyitibwa glabra. Ekirungo kya Glabridin, ekirungo eky’enjawulo ekikola ebiramu ekisangibwa muGlycyrrhiza enviiri eziyitibwa glabra, yeetaaga emyaka egiwerako okukula okukuŋŋaanyizibwa era mu butonde ebeera ku mitendera egya wansi ennyo.
OkuvaKkiro 1,000 ez’ebimera bya G. glabra, okkanga kkiro 0.1 eza glabridinesobola okuggyibwa-omugerageranyo gw'okuggyibwamu ogwa 1:10,000 oguggumiza obutaba bwayo.

Mu kiseera kye kimu, glabridin ayolesaobusobozi obw’amaanyi obw’ekitalo obw’okwerusa, okufuna erinnya lyayo nga"oral super photonic" ekirungo. Yafuna dda okusika omuguwa okw’amaanyi mu by’okulabirira olususu era nga yeettanira nnyo amakampuni amanene agakola ku by’okwewunda.

Ekiziyiza eky’amaanyi ekya Tyrosinase**

Okusukka ku buziyiza bwayo obw’okuziyiza obuwuka obuleeta obulwadde n’okuziyiza okuzimba, omulimu gwa glabridin ogusinga okuba ogw’enjawulo guli mu...ekikolwa eky’amaanyi eky’okuziyiza ku tyrosinase. Mu bikolwa byonna ebimanyiddwa eby’obutonde ebiva mu bimera-, erina abavuganya batono, era amaanyi gaayo ag’okuziyiza gewaggulu nnyookusinga eddagala eriziyiza tyrosinase eritera okukozesebwa ngaasidi wa kojicnearbutin (arbutin) nga.

Okusinziira ku kunoonyereza okufulumiziddwa [2], glabridin akola nga aomulyango gwa molekyu-ekizibiti, okuziyiza okutuuka mu kifo ekiyitibwa catalytic center ekya tyrosinase. Nga tulemesa tyrosine okuyingira mu kifo ekikola n’okuyita mu nkyukakyuka oluvannyuma, glabridin effectivelyetaataaganya okukola kwa melanin ku nsibuko yaayo.

Ekifaananyi 8:
A: Mu butabeerawo glabridin, tyrosine (bbululu omuddugavu) asobola okuyingira mu kifo ekiyitibwa catalytic center (bbululu omutangaavu) n’akyusibwa mpolampola n’afuuka melanin.
B: Mu kubeerawo kwa glabridin (ka kiragala omutangaavu), omulyango oguyingira mu kifo ekiyitibwa catalytic center guzibikira, ekiziyiza tyrosine okuyingira.

Okusinziira ku biwandiiko by’okugezesa okuva mu kitongole eky’ekibiina eky’okusatu- [4], omulimu gw’okuziyiza tyrosinase ogwa Licochalcone A ne LicoSnow licorice extract gusinga nnyo ogw’ebintu ebifaanagana. Okugezesa kwakozesa ekitundu-ekisinga obunene ekiziyiza (IC50) ekya tyrosinase ng’omusingi gw’okwekenneenya. Ekiraga kino kikiikirira obungi bw’ebintu ebisookerwako ebyetaagisa okuziyiza ebitundu 50% eby’emirimu gya tyrosinase. Omuwendo gwa IC50 ogwa wansi gulaga nti ekigimusa kyoleka ebikolwa ebinene eby’okuziyiza ku kigero ekitono, ekiraga okuziyiza kwa tyrosinase okw’amaanyi.

Okusobola okukakasa obwenkanya, okugezesa kwagabanyizibwamu ebibinja bibiri eby’okugeraageranya:

Ekibinja 1: High-purity raw materials (purity >98%), omuli Licochalcone A, glutathione, ergothioneine, ne kojic acid (ekifuga ekirungi eky’okuziyiza tyrosinase), omugatte gwa bintu bina.

Ekibinja 2:Ebiva mu bimera, omuli LicoSnow licorice extract (erimu 4% Licochalcone A), melon concentrate powder (erimu SOD), ne white tomato concentrate powder (erimu dihydro-/tetrahydro-lycopene), omugatte gwa bintu bisatu.

Emiwendo gya IC50 egya buli kigimusa giragibwa mu kipande 2.

Okusinziira ku miwendo gya IC50, omulimu gw’okuziyiza tyrosinase ogw’okugeraageranya ogw’ebibinja byombi gulagibwa mu bifaananyi 9 ne 10. Mu kibinja 1, omulimu gw’okuziyiza tyrosinase ogwa Licochalcone A gukubisaamu emirundi 1.4 ogwa glutathione, emirundi 3 ogwa kojic acid, n’emirundi 141 egya ergothioneine. Mu kibinja 2, omulimu gw’okuziyiza tyrosinase ogw’ekirungo kya LicoSnow licorice extract gukubisaamu emirundi 11 ku butto wa melon concentrate ate emirundi 6,930 ku butto w’ennyaanya enjeru concentrate.

Okukakasa mu bujjanjabi obwerusa mu kamwa ne Licorice

Wadde ng’ekirungo kya Licochalcone A ekyerusa kibadde kimanyiddwa okuva edda mu bannassaayansi era nga kyeyongera okutwalibwa ng’ekikulu mu mulimu gw’okulabirira olususu, tewali kunoonyereza kwa bujjanjabi kwa bantu kufulumiziddwa ku ngeri gye yeerusa mu kamwa kubadde kuloopebwa. Ekirungo kya LicoSnow licorice extract (ekirimu 4% Licochalcone A) kijjuza ddala ekituli kino.

Huasheng Ingredients, nga bakolagana n’ekitongole ekigezesa eky’ekibiina eky’okusatu-ekimanyiddwa ennyo, baakola okugezesebwa kw’abantu okw’omwezi 1-nga kwetabyemu abantu 34 (abakyala ab’emyaka 25–50) [5]. Abeetabye mu kutendekebwa kuno baanywa mu kamwa 100 mg za LicoSnow licorice extract buli lunaku (erimu 4 mg Licochalcone A). Ebikosa okwerusa byakeberebwa okuyita mu bipimo ebisinziira ku bikozesebwa n’ebibuuzo. Ebyavudde mu kugezesa bye bino wammanga:

Okukendeeza ku langi mu maaso (16%↓):
Oluvannyuma lw’ennaku 28 nga banywa, ekitundu kya langi mu maaso kyakendeera okuva ku 19.87% okutuuka ku 16.65%, okukendeera kwa 16.21% (p=0.004), ekiraga enjawulo nnene nga tebannaba kugatta n’oluvannyuma lw’okugatta. Okugeraageranya langi y’amaaso g’abeetabye mu kugezesebwa kulagiddwa mu kifaananyi 11.

Ekifaananyi 11: Enkyukakyuka mu langi ya ffeesi; kkono: nga tonnanywa, ku ddyo: oluvannyuma lw’okukozesa

Okweyongera mu kumasamasa kw’olususu (21%↑):
Oluvannyuma lw’ennaku 28, okumasamasa kw’olususu mu maaso kweyongera okuva ku bitundu 4.0% okutuuka ku bitundu 4.84%, okulongoosa ebitundu 21.00% (p=0.014), ekiraga enjawulo nnene nga tebannaba kugiwa n’oluvannyuma lw’okugiwa. Okugeraageranya okumasamasa kw’olususu lw’abeetabye mu kugezesebwa kulagiddwa mu kifaananyi 12.

Ekifaananyi 12: Enkyukakyuka mu kumasamasa kw’olususu mu maaso; kkono: nga tonnanywa, ku ddyo: oluvannyuma lw’okukozesa

Okukendeeza ku langi ya UV oluvannyuma - (15%↓):
Obutangaavu bwa UV obw’obutonde bwasiigibwa ku migongo gy’abeetabye mu kutendekebwa okusobola okukola ebifo we batandikira. Ennaku bbiri oluvannyuma lw’okubunyisa obusannyalazo, ensaasaanya ya langi yapimibwa okwekenneenya langi ya post-UV. Ebipimo byakolebwa ku ntandikwa y’okugatta (D-2 irradiation, D0 measurement) ne ku nkomerero (D28 irradiation, D30 measurement). Oluvannyuma lw’ennaku 28, emiwendo gya melanin mu bitundu ebisiigiddwa langi yakendeera okuva ku 99 okutuuka ku 84, okukendeera kwa 15.15% (p < 0.001), ekiraga enjawulo nnene nga tebannaba kugatta n’oluvannyuma lw’okugigatta.

Okukendeeza ku kumyuuka kw’olususu (28%↓):
Oluvannyuma lw’ennaku 28, omuwendo gw’okumyuuka (omuwendo gwa a*, emiwendo egy’oku ntikko giraga olususu olumyufu) olw’omugongo gwakendeera okuva ku 10.70 okutuuka ku 7.69, okukendeera kwa 28.13% (p < 0.001), ekiraga enjawulo nnene nga tebannaba kugatta n’oluvannyuma lw’okugatta.

Okutwalira awamu okulongoosa olususu (≈90% ku beetabye mu kugezesebwa bakkiriziganya):
Oluvannyuma lw’ennaku 28, kumpi ebitundu 90% ku beetabye mu kugezesebwa baategeeza nti olususu okutwalira awamu lwalongooka, gamba ng’olususu olulungi era olutangaala, okumasamasa okw’amaanyi, n’okukendeeza ku buzibu bw’okusiiga oba okumyuuka.

Ebikwata ku byokwerinda ebirungi:
Tewali buzibu bwonna bwalabibwa mu kiseera ky’okugezesa.

Ebiwandiiko ebikozesebwa:
[1] Ekitongole ky’okunoonyereza ekya Boguang.2025 China Alipoota y'okunoonyereza ku katale k'obulungi bw'omu kamwa.
[2] Chen J, Yu X, Huang Y., ne bannaabwe abalala.Enkola eziziyiza glabridin ku tyrosinase.Spectrochimica Acta Ekitundu A: Okukebera molekyu n'ebiramu. 2016 Nov 5;168:111-117.
[3] Lipoota y'okugezesa eyafulumizibwa Shenzhen 863 Testing Center.
[4] Lipoota y’okugezesebwa kw’abantu eyafulumizibwa ekitongole kya Huace Testing.